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Bogdan Wlodarczyk, Ph.D.

Research Assistant Professor
Dell Pediatric Research Institute
Department of Pediatrics, The University of Texas at Austin Dell Medical School
(512) 495-3002
bwlodarczyk@austin.utexas.edu

 

About

Dr. Wlodarczyk uses genetically modified mice to reveal how genetic mutations modulate the mechanisms underlying susceptibility to the induction of congenital defects.

Research Interests

I am a research veterinarian who has long been interested in toxicology, especially those aspects concerning human reproduction. More specifically, I am trying to understand why some babies are born with congenital defects while others are healthy and develop normally. Almost 5% of all newborns worldwide are born with birth defects which are directly responsible for millions of infant death worldwide. The study of abnormal development resulting in birth defects is called “teratology”. This field of study really began in the 1960s following the Thalidomide tragedy. Thalidomide was a drug intended for pregnant women to help them reduce the symptoms of morning sickness. Unfortunately it had devastating effects on developing embryos. In 46 different countries, over 10, 000 babies with no hands or legs, or with severely deformed limbs were born in just a few years. Ever since this tragedy occurred, scientists began to study how drugs, pesticides or any other environmental stimuli can disrupt normal embryo/fetal development and cause babies to be born with congenital defects. These studies proved to be very difficult, and although significant progress has been made, about 65% of all identified birth defect cases have no known causes. That means, for every three babies that we see in clinics with birth defects, we have no explanation to give to two sets of parents. This is not an acceptable situation. Today we know that all embryos developing in their mother`s womb are vulnerable to many chemicals that might seem to be non-toxic to adults. We are also now aware that humans carry many mutations in genes which can make certain individuals more susceptible to environmental toxins.
Since one obviously can’t perform toxicological experiments on humans, different models have been used to study birth defects; from cell cultures through frogs, chicken embryos, laboratory rodents and primates to mathematical computational models. My research uses laboratory mice, the conventional and the genetically engineered variety. Pregnant female mice can be used to test new drugs or other chemical compounds intended for ultimate use in humans. Since over 85% of the genes controlling human development have also been found in mice, I recently started using genetically modified mice that carry mutations in specific genes to learn more about the causes of birth defects. Results of these studies not only allow me to understand how specific birth defects arise but also help to identify the population of humans (having a similar mutation) who may be at higher risk of conceiving a baby with congenital defects. Studying birth defects will ultimately result in prevention and eradication of these merciless adverse pregnancy outcomes.

Selected Publications: (for more see PubMed)

  • Hill D., Cabrera R., Wallis Schultz D., Zhu H., Lu W., Finnell RH, Wlodarczyk BJ.
    Autism-like behavior and epigenetic changes associated with autism as consequences of in utero exposure to environmental pollutants in a mouse model.
    Behavioural Neurology 2015
  • Wlodarczyk BJ., Ogle K., Lin LY., Bialer M., Finnell RH.
    Comparative teratogenicity analysis of valnoctamide, risperidone, and olanzapine in mice.
    Bipolar Disord 17(6):615-25, 2015
  • Mawasi H., Shekh-Ahmad T., Finnell R., Wlodarczyk B., Bialer M.
    Structure-Pharmacokinetic-Pharmacodynamic-Relationship Analysis of CNS-Active Constitutional Isomers of Valnoctamide and sec-Butylpropylacetamide - Amide Derivatives of Valproic Acid.
    J Med Chem. 46:72-8, 2015
  • Shekh-Ahmad T, Mawasi H, McDonough JH, Finnell RH, Wlodarczyk BJ, Yavin E, Bialer M.
    Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid.
    Epilepsia. 55 (12):1944-52, 2014
  • Wlodarczyk BJ., Zhu H, Finnell RH.
    Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity.
    Toxicol and Appl Pharmacol. 275(1):22-7, 2014
  • Shekh-Ahmad T., Hen N., Yagen B., McDonough JH., Finnell RH., Wlodarczyk BJ., Bialer M.
    Stereoselective Anticonvulsant and Pharmacokinetic Analysis of Valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential.
    Epilepsia. 55(2):353-61, 2014.
  • Hen N., Shekh-Ahmad T., Yagen B., Finnell R., Wlodarczyk B., Bialer M.
    Stereoselective Pharmacodynamic and Pharmacokinetic Analysis of sec-Butyl-propylacetamide (SPD), a New CNS-Active Derivative of Valproic Acid with Unique Activity against Status Epilepticus
    J Med. Chem 56(16):6467-77, 2013.
  • Tabler JM., Barrell WB., Szabo-Rogers HL., Healy C., Yeung Y., Perdiguero EG., Schulz C., Yannakoudakis BZ., Mesbahi A., Wlodarczyk B., Geissmann F., Finnell RH., Wallingford JB., Liu KJ.
    Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF related syndromes.
    Dev Cell. 25(6):623-635, 2013.
  • Lai SC, Nakayama Y, Sequeira JM, Wlodarczyk BJ, Cabrera RM, Finnell RH, Bottiglieri T, Quadros EV.
    The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system.
    FASEB 6:2468-75, 2013.
  • Denny KJ, Coulthard LG, Jeanes A, Lisgo S, Simmons DG, Callaway LK, Wlodarczyk B, Finnell RH, Woodruff TM, Taylor SM.
    C5a Receptor Signaling Prevents Folate Deficiency-Induced Neural Tube Defects in Mice.
    J Immunol 190(7):3493-9, 2013
  • Wlodarczyk B., Spiegelstein O., Hill D., Le X. Chris, Finnell RH.
    Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate.
    Tox Lett 215(3):214-8, 2012.
  • Cabrera RM, Finnell RH, Zhu H, Shaw GM, Wlodarczyk BJ.
    Transcriptional Analyses of Two Mouse Models of Spina Bifida.
    Birth Defects Res B 94(10):782-789, 2012.
  • Wlodarczyk BJ., Palacios AM., George TM., Finnell RH.
    Antiepileptic Drugs and Pregnancy Outcomes.
    Am J Med Genet A 158A(8):2071-90, 2012.
  • Psychoyos D., Vinod KY., Cao J., Xie S., Hyson RL., Wlodarczyk B., He W., Cooper TB., Hungund BL., Finnell RH.
    Antiepileptic Drugs and Pregnancy Outcomes.
    Birth Defects Res B Dev Reprod Toxicol 95(2):137-50, 2012.
  • Pessah N, Yagen B. Hen N, Shimshoni J, Wlodarczyk B, Finnell RH, Bialer M.
    Design and Pharmacological Activity of Glycinamide and N-Methoxy-Amide Derivatives of Analogues and Constitutional Isomers of Valproic Acid.
    Epilepsy & Behavior Nov 2011;22(3):461-8
  • Zhang Z, Wlodarczyk B, Niederreither K, Venugopalan S, Florez S, Finnell R, Amendt BA.
    Fuz Regulates Craniofacial Development Through Tissue Specific Responses to Signaling Factors.
    Plos ONE. 2011;6(9):e24608
  • Wlodarczyk BJ, Palacios AM, Chapa CJ, Zhu H, George TM, Finnell RH.
    Genetic basis of susceptibility to teratogen induced birth defects.
    Am J Med Genet C Semin Med Genet. 157(3):215-26, 2011.
  • Dai D, Zhu H, Wlodarczyk B, Zhang L, Li L, Li AG, Finnell RH, Roop DR, Chen J.
    Fuz Controls the Morphogenesis and Differentiation of Hair Follicles through the Formation of Primary Cilia.
    Journal of Investigative Dermatology. 131(2):302-10, 2011.
  • Pessah N., Kaufmann D., Yagen B., Hen N., Wlodarczyk B., Finnell R., Bialer M.
    Comparative Pharmacodynamic and Pharmacokinetic Analysis of Two Anticonvulsant Halo Derivatives of 2,2,3,3-Tetramethylcyclopropane Carboxamide, an Amide of a Cyclic Analogue of Valproic Acid.
    Epilepsia. 51(10):1944-53, 2010.
  • Hill DS, Wlodarczyk BJ, Palacios A, Finnell RH.
    Update on the teratogenicity of antiepileptic drugs.
    Expert Rev Neurother. 10(6): 943-59, 2010.
  • Hen N, Bialer M, Wlodarczyk B, Finnell RH, Yagen B.
    Syntheses And Evaluation Of Anticonvulsant Profile And Teratogenicity Of Novel Amide Derivatives Of Branched Aliphatic Carboxylic Acids With 4-Amino-Benzensulfonamide.
    Journal of Medical Chemistry 53(10): 4177-86, 2010.
  • Kaufmann D., Yagen B., Minert A., Wlodarczyk B., Finnell RH., Schurig V., Devor M., and Bialer M.
    Evaluation of the Antiallodynic, Teratogenic and Pharmacokinetic Profile of Stereoisomers of Valnoctamide, an Amide Derivative of a Chiral Isomer of Valproic Acid.
    Neuropharmacology 58(8): 1228-1236, 2010.
  • Hill D, Wlodarczyk B, Mitchell L, Finnell RH.
    Arsenate induced maternal hyperglycemia and neural tube defects in a mouse model.
    Toxicology and Applied Pharmacology. 239(1): 29-36, 2009.
  • Shimshoni JA, Yagen B, Wlodarczyk B, Finnell RH, Schurig V, and Bialer M.
    Evaluation of Stereoselective Anticonvulsant, Teratogenic and Pharmacokinetic Profile of Valnoctylurea (Capuride): A Chiral Stereoisomer of Valproic Acid Urea Derivative.
    Epilepsia 51(3): 323-332, 2009.
  • Gray RS, Abitua PB, Wlodarczyk B., Szabo-Rogers HL, Blanchard O, Lee I, Weiss GS, Liu KJ, Marcotte EM, Wallingford JB, Finnell RH.
    The planar cell polarity effector Fuz is essential for targeted membrane trafficking ciliogenesis and mouse embryonic development.
    Nature Cell Biology 11(10): 1225-32, 2009.
  • Pessah N, Bialer M, Wlodarczyk B, Finnell R, Yagen B.
    α-Fluoro-2,2,3,3-Tetramethylcyclopropanecarboxamide a Novel Potent Anticonvulsant Derivative of a Cyclic Analogue of Valproic Acid.
    Journal of Medical Chemistry 52(8): 2233-42, 2009.
  • Shimshoni JA, Yagen B, Pessah N, Wlodarczyk B, Finnell RH, Bialer M.
    Anticonvulsant profile and teratogenicity of 3,3-dimethylbutanoylurea: A potential for a second generation drug to valproic acid.
    Epilepsia 49(7): 1202- 12. 2008
  • Hill, D.S., Wlodarczyk, B., Finnell, R.H.
    Reproductive consequences of oral arsenate exposure during pregnancy in a mouse model.
    Birth Defects Res B Dev Reprod Toxicol. 83(1):40-47, 2008.
  • Wong RL., Wlodarczyk BJ., Min KS., Scott ML., Kartiko S., Yu W., Merriweather MY., Vogel P., Zambrowicz BP., Finnell RH.
    Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube.
    Hum. Mol. Genet. 17(4):587-601, 2008.
  • Zhu H., Cabrera R., Wlodarczyk BJ., Bozinov D., Wang D., Schwartz RJ., Finnell RH.
    Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity.
    BMC Dev Biol. 7(1):128-133, 2007.
  • Shimshoni JA., Bialer M., Wlodarczyk B., Finnell RH., Yagen B.
    Potent Anticonvulsant Urea Derivatives of Constitutional Isomers of Valproic Acid.
    J Med Chem. 50(25):6419-6427, 2007.
  • Zhu H., Wlodarczyk B., Scott M., Yu W., Merriweather M., Gelineau-Van Waes J., Schwartz R., Finnell R.
    Cardiovascular abnormalities in Folr1 knockout mice and folate rescue.
    Birth Defects Research Part A: Clinical and Molecular Teratology 79(4): 257-68, 2007.
  • Sobol E., Yagen B., Lamb L.G., White H.S., Wlodarczyk B.J., Finnell R.H.
    Bialer M. Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide.
    Epilepsy Research 73: 75-84, 2007.
  • Sobol E., Yagen B., White H.S., Wilcox K.S., Lamb J.G., Pappo O., Wlodarczyk B.J., Finnell R.H., Bialer M.
    Preclinical Evaluation of 2,2,3,3-Tetramethyl-cyclopropanecarbonyl-urea a Novel, Second Generation to Valproic Acid, Antiepileptic Drug.
    Neuropharmacology 51: 933-946, 2006.
  • Wlodarczyk B.J., Cabrera R.M., Hill D.S., Bozinov D., Zhu H., Finnell R.H.
    Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos.
    Neurotoxicology 27(4):547-557, 2006.
  • Massa V., Wlodarczyk B., Giavini E., Finnell RH.
    Myo-Inositol enhances teratogenicity of valproic acid in the mouse.
    Birth Defect Research (Part A) 76(3): 200-204 2006.
  • Abdelrahim M., Ariazi E., Kim K., Khan S., Barhoumi R., Burghardt R., Liu S., Hill D., Finnell R., Wlodarczyk B., Jordan VC.,
    Safe S. 3-Methylcholanthrene and Other Aryl Hydrocarbon Receptor Agonists Directly Activate Estrogen Receptor α.
    Cancer Research 66(4): 2459-2467, 2006.
  • Wlodarczyk B.J., Tang L.S., Triplett A., Aleman F., Finnell R.H.
    Spontaneous Neural Tube Defects in Splotch Mice Supplemented with Selected Micronutrients.
    Toxicology and Applied Pharmacology 213(1): 55-63, 2006
  • Tang L.S, Miranda R.C, Santillano D.R, Wlodarczyk B.J, Finnell R.H.
    Role of Folbp1 in the Regional Regulation of Apoptosis and Cell Proliferation in the Developing Neural Tube and Craniofacies.
    American Journal of Medical Genetics 135(1): 48-58, 2005.
  • Spiegelstein O., Gould A., Wlodarczyk B., Tsie M., Lu X., Le C., Troen A., Selhub J., Piedrahita J.A., Salbaum J.M., Kappen C., Melnyk S., James J., Finnell R.H.
    Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiences.
    Toxicology and Applied Pharmacology 203(1): 18-26, 2005.
  • Tang L.S, Wlodarczyk B.J, Santillano D.R, Miranda R.C, Finnell R.H.
    Developmental consequences of abnormal folate transport during murine heart morphogenesis.
    Birth Defects Res Part A Clin Mol Teratol. 70(7): 449-58, 2004.
  • Spiegelstein O., Cabrera R.M., Bozinov D., Wlodarczyk B., Finnell R.H.
    Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos.
    Neurochem Res. 29(6): 1105-1112, 2004.
  • Isoherranen N., Yagen B., Spiegelstein O., Finnell R.H., Merriweather M., Woodhead J.H., Wlodarczyk B., White H.S., Bialer M.
    Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice.
    British Journal of Pharmacology 139(4): 755-764, 2003.
  • Wlodarczyk B.
    Congenital defects of central nervous system - arsenic induced disruption in neural tube gene expression.
    Habilitation thesis. NVRI edition, 2002.
  • Minta M., Biernacki B., Wlodarczyk B.
    Fluorine toxicity in primary stem cell culture.
    In "Metabolism fluoru" T. Ogoński, D. Samujlo and Z. Machoy (eds.). PAM Szczecin: 166-173, 2002.
  • Finnell R.H., Spiegelstein O., Wlodarczyk B., Triplett A, Pogribny I.P., Melnyk S, James J.S.
    DNA methylation in folbp1 knockout mice supplemented with folinic acid during gestation.
    J Nutrition 132: 2457S-2461S, 2002.
  • Szprengier-Juszkiewicz T., Semeniuk S., Wlodarczyk B.
    Plasma kinetics and tissue residues of fenbendazole following oral administration to pigs.
    Bulletin of the Veterinary Institute in Pulawy vol. 46 (1): 119-125, 2002.
  • Finnell, R.H., Wlodarczyk, B., Spiegelstein, O., Triplett, A. & Gelineau-vanWaes, J.
    Folate transport abnormalities and congenital defects.
    In Milstein, S., Kapatos, G., Levine, R.A. & Shane, B., eds. Chemistry and Biology of Pteridines and Folates. Kluwer Academic Publishers, Norwich, MA pp. 637-642, 2001
  • Wlodarczyk B., Spiegelstein O., Gelineau-van Waes J., Vorce R.L., Lu X., Le Ch.X., Finnell R.H.
    Arsenic-Induced Congenital Malformations in Genetically Susceptible Folate Binding Protein-2 (Folbp2) Knockout Mice.
    Toxicology and Applied Pharmacology 177 (3): 238-246, 2001.
  • Wlodarczyk B., Biernacki B., Minta M.
    Teratogenic action of antiepileptic drug: 2-propylpentanoic acid - effects on rat and hamster embryos cultured in vitro.
    Ginekologia Polska 72 (12): 955-960, 2001.
  • Wlodarczyk B., Biernacki B., Minta M., Zmudzki J.
    Postimplantation whole embryo culture assay for hamsters: an alternative to rat and mouse.
    The Scientific World 1 227-234, 2001.
  • Biernacki B., Wlodarczyk B., Minta M.
    Evaluation of the developmental toxicity of gentamicin using postimplantation rat whole embryo culture.
    Bulletin of the Veterinary Institute in Pulawy vol. 45 (2): 347-352, 2001.
  • Barber R., Wlodarczyk B. and Kenyon J.
    High throughput screening of single nucleotide polymorphisms (SNPs) using the BESS-T&G Base Reader Kit and the ABI PRISM 3700 DNA sequencer.
    Epicentre Forum 7 (3):1-3, 2000.
  • Finnell R.H., Gelineau-van Waes J., Bennett G.D., Barber R.C., Wlodarczyk B., Show G.M., Lammer E.J., Piedrahita J.A., Eberwine J.H.
    Genetic basis of susceptibility to environmentally induced neural tube defects.
    Annales of the New York Academy of Sciences 919: 261-277, 2000
  • Eudy J.D., Spiegelstein O., Barber R.C., Wlodarczyk B., Talbot J., Finnell R.H.
    Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family micronutrient transporter genes.
    Molecular Genetics and Metabolism 71(4): 581-90, 2000.
  • Bennett G.D., Wlodarczyk B., Calvin J.A., Craig J.C., Finnell R.H.
    Valproic acid-induced alterations in growth and neurotrophic factor gene expression in murine embryos.
    Reproductive Toxicology 14 (1): 1-11, 2000.
  • Biernacki B., Wlodarczyk B., Minta M.
    Effect of sodium valproate on rat embryo development in vitro.
    Bulletin of the Veterinary Institute in Pulawy 44 (2): 201-206, 2000.
  • Wlodarczyk B., Minta M., Biernacki B., Szkoda J., Żmudzki J.
    Selenium protection gaainst cadmium toxicity in hamster embryos.
    Polish Journal of Environmental Studies 9 (4): 323 - 327, 2000
  • Wlodarczyk B., Biernacki B., Minta M., Żmudzki J.
    Hamster whole-embryo culture as a new in vitro model for teratogenicity testing.
    Polish Journal of Veterinary Science 2 (4): 149-153, 1999.
  • Finnell R.H., Bennett G.D., Mather G.G., Wlodarczyk B., Bajpai M., Levy R.H.
    Effect of stiripentol dose on phenytoin-induced teratogenesis in a mouse model.
    Reprod. Toxicol. 13 (2): 85-91, 1999.
  • Szkoda J., Minta M., Biernacki B., Wlodarczyk B.
    Fluorine concentration in maternal and fetal tissues of rodents after experimental exposure to sodium fluoride in drinking water.
    In "Fluorine and bioelements in biology and medicine". T. Ogoński, D. Samujlo and Z. Machoy (eds.). PAM Szczecin, pp. 89-94, 1998.
  • Minta M., Biernacki B., Wlodarczyk B.
    Prenatal toxicity of fluorine: summary results from studies on rodents. In: Fluorine and bioelements in biology and medicine.
    T. Ogoński, D. Samujlo and Z. Machoy (eds.). PAM Szczecin, pp. 33-39, 1998.
  • Minta M., Wlodarczyk B., Biernacki B., Szkoda J.
    Experimental embryotoxicology of fluorine. In: Biological risk caused by fluorine compounds.
    Z. Machoya and D. Samujlo (eds.). PAAM Szczecin, pp. 62-66, 1998.
  • Biernacki B., Wlodarczyk B., Minta M.
    Micrometric and morphological assessment of early stage rat embryos - application for in vitro teratology testing.
    Ginekologia Polska LXIX (12): 919-921, 1998.
  • Biernacki B., Wlodarczyk B., Minta M.
    Postimplantation rat embryo-culture.
    Preliminary study. Acta Poloniae Toxicologica 6 (2): 265-269, 1998.
  • Minta M., Wlodarczyk B., Biernacki B., Żmudzki J.
    Possibilities for the reduction of the number of animals in toxicological experiments.
    Med. Wet. 54 (10): 663-666, 1998.
  • Minta M., Biernacki B., Wlodarczyk B., Żmudzki J.
    Effect of a long-term action of small doses of sodium fluoride on pregnant female rats and their fetuses.
    Bulletin of the Veterinary Institute in Pulawy vol. 42, No. 1: 45-53, 1998.
  • Wlodarczyk B., Minta M., Biernacki B.
    Spermatotoxic effects of the fungicide benlate on the reproductive system in male hamsters.
    Acta Poloniae Toxicologica 5 (2): 141-148, 1997.
  • Minta M,. Wlodarczyk B., Biernacki B., Żmudzki J.
    Sodium fluoride and pregnancy. Effect on reproductive parameters in hamsters.
    Acta Poloniae Toxicologica 5 (1): 55-61, 1997.
  • Biernacki B., Wlodarczyk B.
    Obtaining of postimplantation rat embryos for in vitro teratology examinations.
    Ginekologia Polska LXVIII, No 5b: 51-53, 1997.
  • Craig J.C., Eberwine J.H., Calvin J.A., Wlodarczyk B., Bennett G.D., Finnell R.H.
    Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology.
    Biochemical and Molecular Medicine, 60 (2): 81-91, 1997.
  • Finnel R.H., Wlodarczyk B., Craig J.C., Piedrahita H., Bennett G.D.
    Strain dependent alteration in the expression of folate pathway genes following teratogenic exposure to valproic acid in mouse model.
    American Journal of Medical Genetics, 70: 303-311, 1997.
  • Wlodarczyk B., Craig J.C., Bennett G.D., Calvin J.A., Finnell R.H.
    Valproic acid induced changes in gene expression during neurulation in mouse model.
    Teratology, 54 (6): 284-297, 1996.
  • Minta M., Wlodarczyk B.
    Toxicology of reproduction in view of alternative methods.
    Medycyna Pracy XLVII nr 5, suplement 6: 93-103, 1996.
  • Wlodarczyk B., Bennett G.D., Calvin J.A, Finnell R.H.
    Arsenic- induced neural tube defects in mice: alteration in cell cycle gene expression.
    Reproductive Toxicology, 10: 447-454, 1996.
  • Bennett G.D., Amore B.M., Finnell R.H., Wlodarczyk B., Kalhorn T.F., Skiles G.L., Nelson S.D., Slattery J.T.
    Teretogenicity of carbamazepine-10, 11- epoxide and oxcarbazepine in the SWV mouse.
    Journal of Pharmacology and Experimental Therapeutics, 279: 1237-1242, 1996.
  • Wlodarczyk B., Bennett G.D., Calvin J.A., Craig J.C., Finnell R.H.
    Arsenic-induced alterations in embryonic transcription factor gene expression: implications for abnormal neural development.
    Developmental Genetics 18: 306-315, 1996.
  • Minta M., Biernacki B., Wlodarczyk B.
    Effect of cadmium on the prenatal development of hamsters and rats.
    Bulletin of the Veterinary Institute in Pulawy vol. 40, No. 1: 31-39, 1996.
  • Minta M., Wlodarczyk B., Biernacki B., Szkoda J., Juszkiewicz T.
    Selenium embryotoxicity in hamster following exposure to sodium selenite.
    Actae Poloniae Toxicologica 3 (2): 134-138, 1995.
  • Minta M., Biernacki B., Wlodarczyk B.
    Prenatal toxicity of dimethoate in hamsters, rats and rabbits.
    Bulletin of the Veterinary Institute in Pulawy vol. 39, No. 2: 125-131, 1995.
  • Wlodarczyk B., Biernacki B., Minta M., Kozaczynski W., Juszkiewicz T.
    Male golden hamster in male reproductive toxicology testing: Assessment of protective activity of selenium in acute cadmium intoxication.
    Bulletin of Environmental Contamination and Toxicology 6 (54): 907-912, 1995.